Article
Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jun 2012
Edlund Karolina, Larsson Ola, Ameur Adam, Bunikis Ignas, Gyllensten Ulf, Leroy Bernard, Sundström Magnus, Micke Patrick, Botling Johan, Soussi Thierry
Abstract excerpt
Cancer mutation databases are expected to play central roles in personalized medicine by providing targets for drug development and biomarkers to tailor treatments to each patient. The accuracy of reported mutations is a critical issue that is commonly overlooked, which leads to mutation databases that include a sizable number of spurious mutations, either sequencing errors or passenger mutations. Here we report...
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