Article

In-Silico Reclassification of TP53 Variants of Uncertain Significance (VUS) Integrating Ensemble Predictors, Evolutionary Conservation, and 3D Structural Dynamics

2026-08-28

Abstract excerpt

<title>Abstract</title> <p> Variants of Uncertain Significance (VUS) in the <italic>TP53</italic> tumor suppressor gene present a significant challenge in clinical oncology, leaving critical patient genomic alterations unresolved. In this study, a multi-layered computational variant reclassification pipeline was developed to evaluate 625 missense <italic>TP53</italic> VUS entries extracted from ClinVar. Geno...

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Literature Corpus work: bb2d7758-7976-50d1-a47a-83f2c83fcecf
DOI: 10.21203/rs.3.rs-10843926/v1

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