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Article

TGF-β induces a heart failure phenotype via fibroblasts exosome signaling

1 Oct 2019

Abstract excerpt

PURPOSE: The mechanisms for persistent and progressive loss of myocardial function in advanced heart failure (HF) remain incompletely characterized. In the current study, we sought to determine the impact of TGF-β on fibroblasts transcriptional profiles and assess if exosomes from TGF-β treated fibroblasts could induce a heart failure phenotype in co-cultured cardiomyocytes. METHOD: Normal heart fibroblasts were...

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Identifiers

PMID: 31687497
DOI: 10.1016/j.heliyon.2019.e02633

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