Article

Local emergence and decline of a SARS-CoV-2 variant with mutations L452R and N501Y in the spike protein

2021-04-29

Abstract excerpt

<h4>Summary</h4> Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are replacing the initial wild-type strain, jeopardizing current efforts to contain the pandemic. Amino acid exchanges in the spike protein are of particular concern as they can render the virus more transmissible or reduce vaccine efficacy. Here, we conducted whole genome sequencing of SARS-CoV-2 positive samples from the Rh...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95212961-0c49-5de7-ae24-3d82d4358fed
DOI: 10.1101/2021.04.27.21254849

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Local emergence and decline of a SARS-CoV-2 variant with mutations L452R and N501Y in the spike proteinDOI 10.1101/2021.04.27.21254849Read

SARS-CoV-2 Variants and Their Relevant Mutational Profiles: Update Summer 2021.Semantic proximity Read

Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates.Semantic proximity Read

Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolatesSemantic proximity Read

Mutations in SARS-CoV-2 Leading to Antigenic Variations in Spike Protein: A Challenge in Vaccine DevelopmentSemantic proximity Read

The spike glycoprotein of SARS-CoV-2: A review of how mutations of spike glycoproteins have driven the emergence of variants with high transmissibility and immune escape.Semantic proximity Read

Large-scale population analysis of SARS-CoV-2 whole genome sequences reveals host-mediated viral evolution with emergence of mutations in the viral Spike protein associated with elevated mortality ratesSemantic proximity Read

A review on evolution of emerging SARS-CoV-2 variants based on spike glycoprotein.Semantic proximity Read

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2Semantic proximity Read

Research progress in spike mutations of SARS-CoV-2 variants and vaccine development.Semantic proximity Read

Emerging mutations in spike and other structural proteins of SARS-CoV-2Semantic proximity Read

Sars-Cov-2 Evolution from the Beginning of Concern to FutureSemantic proximity Read

Global Prevalence of Adaptive and Prolonged Infections' Mutations in the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein.Semantic proximity Read