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Genotypic identification of polyclonal plasma cells in plasma cell dyscrasias shows an aberrant single-cell phenotype with clinical implications

2024-05-27

Abstract excerpt

<h4>SUMMARY</h4> Multiple Myeloma (MM) is driven by clonal plasma cell (PC)-intrinsic factors and changes in the tumorigenic microenvironment (TME). To investigate if residual polyclonal PCs (pPCs) are disrupted, single-cell (sc) RNAseq and sc B-cell receptor analysis were applied in a cohort of 46 samples with PC dyscrasias and 18 healthy donors (HDs). Out of n= 213,074 CD138 pos PCs, 42,717 were genotypically...

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Literature Corpus work
f3050b48-3936-537e-87a6-97ffee5b1fe4
DOI
10.1101/2024.05.26.595470
Open publication

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Genotypic identification of polyclonal plasma cells in plasma cell dyscrasias shows an aberrant single-cell phenotype with clinical implicationsDOI 10.1101/2024.05.26.595470
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