Article

Longitudinal per-lesion <i>in vivo</i> imaging reveals allele-dependent resistance evolution in EGFR-mutant lung cancer

2026-04-18

Abstract excerpt

Acquired resistance to targeted therapies remains an inevitable outcome in EGFR-mutant non-small cell lung cancer, yet the spatiotemporal dynamics through which resistant clones emerge and evolve in vivo remain incompletely understood. In particular, how distinct oncogenic EGFR alleles shape evolutionary trajectories under therapeutic pressure within native tumor microenvironments remains unclear. Here, we estab...

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Literature Corpus work: f2a5971c-5d13-5f79-bfb9-6880bbde4ce3
DOI: 10.64898/2026.04.17.717686

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