Article
Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma
2024-03-29
Abstract excerpt
<title>Abstract</title> <p>Peroxiredoxin 6 (PRDX6) is one of the Peroxiredoxin family members with only 1-Cys, using glutathione as the electron donor to reduce peroxides in cells. PRDX6 has been frequently studied and its expression was associated with poor prognosis in many tumors. However, the expression of PRDX6 in multiple myeloma (MM) and its relevance with MM remain unclear. In our study, we found that PRD...
Topics
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- Cancer, Stress, Anesthesia, and Immune Response
- Cancer therapeutics and mechanisms
- Ferroptosis and cancer prognosis
- Glutathione Transferases and Polymorphisms
- Histone Deacetylase Inhibitors Research
- Multiple Myeloma Research and Treatments
- Redox biology and oxidative stress
- Ubiquitin and proteasome pathways
Identifiers and source
- Literature Corpus work
- a5e9eee8-7810-573e-8069-32c84721615e
- DOI
- 10.21203/rs.3.rs-4088599/v1
