Article

BMI and Varus Malalignment Compound to Define a High-Risk Phenotype for Compartment-Specific Knee Osteoarthritis Progression

2026-04-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Knee osteoarthritis (KOA) is a leading cause of disability, yet which patients will experience structural decline remains unclear. Body mass index (BMI) and lower limb alignment are established risk factors for KOA, but their independent and interactive effects on compartment-specific cartilage loss and total knee replacement (TKR) have not been characterized at scale. <h4>M...

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Literature Corpus work: ecb066f7-af8d-5bcf-81be-a85e5c57a0fc
DOI: 10.64898/2026.04.15.26350819

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