Sex disparate gut microbiome and metabolome perturbations precede disease progression in a mouse model of Rett syndrome

Abstract excerpt

<title>Abstract</title> <p>Rett syndrome (RTT) is a severe regressive neurodevelopmental disorder in girls, characterized by multisystem complications including gut dysbiosis and altered metabolism. While RTT is known to be caused by mutations in the X-linked gene <italic>MECP2</italic>, the intermediate molecular pathways of progressive disease phenotypes are unknown. <italic>Mecp2</italic> knockout rodents used...

Topics

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• Cerebral Cortex
• Disease Models, Animal
• Disease Progression
• Gastrointestinal Microbiome
• Methyl-CpG-Binding Protein 2
• Mutation
• Rats
• Rett Syndrome

Identifiers and source

Literature Corpus work

f26ed61e-5777-5104-9010-d71828d27ba8

DOI

10.21203/rs.3.rs-478134/v1