Article

Mechanistic Insights into Human Antimicrobial Peptide-Induced Activation of a Broadly Conserved Bacterial Signaling System

2025-05-06

Abstract excerpt

Antimicrobial peptides (AMPs) represent a promising class of therapeutics against bacterial pathogens. While their direct bactericidal mechanisms are well-characterized, how bacteria sense and respond to these peptides at sublethal concentrations remains poorly understood. Here, we investigate the activation of the Escherichia coli PhoQ-PhoP signaling system by the human antimicrobial peptide LL-37 and its deriva...

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Literature Corpus work: f25ebe92-8921-5201-8623-72a9624e8d20
DOI: 10.1101/2025.05.06.652532

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