Article
Identification of intracellular target of antimicrobial peptide EWAMP-R in bacteria.
Communications biology - 10 Mar 2026
Wu Yizhao, Tang Hao, Hao Puguo, Xu Yunxiang, Zhang Yifan, Wang Muyuan, Jiang Rui, Jiang Jibao, Zhao Qi, Li Yinsheng
Abstract excerpt
Antimicrobial peptides (AMPs) exhibit diverse antibacterial mechanisms. To elucidate the intracellular targets of the novel AMP, EWAMP-R, we generate EWAMP-R-resistant strains of Escherichia coli and Staphylococcus aureus. In E. coli, a nonsynonymous mutation in the clpX gene (1108 C > T) is identified, resulting in an amino acid change in ClpX (R370C). This mutation confers enhanced tolerance to EWAMP-R and...
Topics
- Escherichia coli
- Staphylococcus aureus
- Antimicrobial Peptides
- Antimicrobial Cationic Peptides
- Anti-Bacterial Agents
- Mutation
- Drug Resistance, Bacterial
- Bacterial Proteins
- Endopeptidase Clp
- Escherichia coli Proteins