Article

High-throughput discovery of peptide activators of a bacterial sensor kinase

2021-06-01

Abstract excerpt

Bacteria use two-component system (TCS) signaling pathways to sense and respond to peptides involved in host defense, quorum sensing, and inter-bacterial warfare. However, little is known about the peptide-sensing capabilities of these TCSs. Here, we develop a high-throughput E. coli display method to characterize the effects of human antimicrobial peptides (AMPs) on the pathogenesis-regulating TCS PhoPQ of Salm...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 30f953a8-7148-57e5-8888-8a6ebd1abbd2
DOI: 10.1101/2021.06.01.446581

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-throughput discovery of peptide activators of a bacterial sensor kinaseDOI 10.1101/2021.06.01.446581Read

Targeting multiple response regulators of Mycobacterium tuberculosis augments the host immune response to infection.Semantic proximity Read

Pangenome analytics reveal two-component systems as conserved targets in ESKAPEE pathogensSemantic proximity Read

Antibody-Recruiting Protein-Catalyzed Capture Agents to Combat Antibiotic-Resistant BacteriaSemantic proximity Read

The PhoQ-activating potential of antimicrobial peptides contributes to antimicrobial efficacy and is predictive of the induction of bacterial resistance.Semantic proximity Read

Mechanistic Insights into Human Antimicrobial Peptide-Induced Activation of a Broadly Conserved Bacterial Signaling SystemSemantic proximity Read

Genome Sequencing Reveals a Large and Diverse Repertoire of Antimicrobial PeptidesSemantic proximity Read

Structure–Activity Relationships of the Competence Stimulating Peptide in Streptococcus mutans Reveal Motifs Critical for Membrane Protease SepM Recognition and ComD Receptor ActivationSemantic proximity Read

A broadly distributed new class of quorum sensing signals mediate bacterial intercellular signalingSemantic proximity Read

Signal-independent activation reveals two-component regulatory networksSemantic proximity Read

AI-Driven Two-Component System Classifier for Pediatric MDR PathogensSemantic proximity Read

Chemoproteomic Profiling Reveals the Mechanism of Bile Acid Tolerance in BacteriaSemantic proximity Read

Systematic Discovery of Antibacterial and Antifungal Bacterial ToxinsSemantic proximity Read