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Article

Detoxification of methylglyoxal by the glyoxalase system is required for glutathione availability and virulence activation in Listeria monocytogenes.

PLoS pathogens - 1 Aug 2021

Anaya-Sanchez Andrea, Feng Ying, Berude John C, Portnoy Daniel A

Abstract excerpt

Listeria monocytogenes is a Gram-positive, food-borne pathogen that lives a biphasic lifestyle, cycling between the environment and as a facultative intracellular pathogen of mammals. Upon entry into host cells, L. monocytogenes upregulates expression of glutathione synthase (GshF) and its product, glutathione (GSH), which is an allosteric activator of the master virulence regulator PrfA. Although gshF mutants...

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Share to Gene Expression Regulation, Bacterial
Share to Glutathione

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34407151
DOI: 10.1371/journal.ppat.1009819
PMCID: PMC8372916

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Detoxification of methylglyoxal by the glyoxalase system is required for glutathione availability and virulence activation in Listeria monocytogenes.PMID 34407151Read ↗

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