Article

Long-read genome sequencing reveals complex variability in lentiviral provirus insertions in deeply characterized Clonal CD19 CAR-T vector copy number reference cell lines

2026-06-16

Abstract excerpt

Chimeric antigen receptor (CAR)-T cell therapy is an important therapy involving provirus insertions in the genome. Characterizing these insertions is important for understanding the safety and efficacy of cell products, but the sequence of these insertions is not fully characterized. We generate clonal CD19 CAR-T cell lines with one to five copies of the lentiviral provirus insertions. Vector copy number (VCN) wa...

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Literature Corpus work: f25595a9-31fd-5957-93fa-a4f9fac54200
DOI: 10.64898/2026.06.15.731627

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Long-read genome sequencing reveals complex variability in lentiviral provirus insertions in deeply characterized Clonal CD19 CAR-T vector copy number reference cell linesDOI 10.64898/2026.06.15.731627Read

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