Article

Application of Droplet Digital PCR for the Detection of Vector Copy Number in Clinical CAR/TCR T-Cell Products

2020-05-13

Abstract excerpt

<h4>Background: </h4> Genetically engineered T cells have become an important therapy for B-cell malignancies. Measuring the efficiency of vector integration into the T cell genome is important for assessing the potency and safety of these cancer immunotherapies. <h4>Methods:</h4> A digital droplet polymerase chain reaction (ddPCR) assay was developed and evaluated for assessing the average number of lenti- and re...

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Literature Corpus work: 7597bad3-7634-5308-a915-8fb78960ddbf
DOI: 10.21203/rs.3.rs-19725/v2

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