Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GENE-IS: Time-Efficient and Accurate Analysis of Viral Integration Events in Large-Scale Gene Therapy Data

16 Dec 2016

Abstract excerpt

Integration site profiling and clonality analysis of viral vector distribution in gene therapy is a key factor to monitor the fate of gene-corrected cells, assess the risk of malignant transformation, and establish vector biosafety. We developed the Genome Integration Site Analysis Pipeline (GENE-IS) for highly time-efficient and accurate detection of next-generation sequencing (NGS)-based viral vector...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Viral gastroenteritis research and epidemiology
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28325279
DOI: 10.1016/j.omtn.2016.12.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GENE-IS: Time-Efficient and Accurate Analysis of Viral Integration Events in Large-Scale Gene Therapy DataPMID 28325279Read ↗

IS-Seq: a bioinformatics pipeline for integration sites analysis with comprehensive abundance quantification methodsSemantic proximity Read ↗

LISA: A Comprehensive R Package for Lentiviral Integration Site Analysis in Gene Therapy Safety AssessmentSemantic proximity Read ↗

Integration Site Analysis in Gene Therapy Patients: Expectations and RealitySemantic proximity Read ↗

Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell productsSemantic proximity Read ↗

HPV, HBV, and HIV-1 Viral Integration Site Mapping: A Streamlined Workflow from NGS to Genomic Insights of CarcinogenesisSemantic proximity Read ↗

ISAnalytics enables longitudinal and high-throughput clonal tracking studies in hematopoietic stem cell gene therapy applicationsSemantic proximity Read ↗

Modeling integration site data for safety assessment with MELISSASemantic proximity Read ↗

Analysis of polyclonal vector integration sites using Nanopore sequencing as a scalable, cost-effective platformSemantic proximity Read ↗

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration SitesSemantic proximity Read ↗

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration SitesSemantic proximity Read ↗

An analytical pipeline for identifying and mapping the integration sites of HIV and other retrovirusesSemantic proximity Read ↗

VISDB: a manually curated database of viral integration sites in the human genomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.