Article

LVV SMRTcap reveals extensive proviral variation in lentiviral vector-transduced CAR T cells

2026-05-15

Abstract excerpt

Lentiviral vectors are commonly used to introduce chimeric antigen receptor transgenes into T cells, but routine assays quantify vector copy number or integration sites without sequencing full-length integrated vectors. HIV-1 proviruses often acquire large deletions and cytidine deaminase-driven hypermutation; whether similar variation occurs in therapeutic lentiviral vectors is unclear. We adapted a novel long-re...

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Literature Corpus work: 4746ab4b-4f14-5ca1-a159-a2da01fb06e6
DOI: 10.64898/2026.05.13.724601

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