Article

Development of an optimized, non-stem cell line for intranasal delivery of therapeutic cargo to the central nervous system

2023-08-17

Abstract excerpt

Neural stem cells (NSC) are considered to be valuable candidates for delivering a variety of anti-cancer agents to brain tumors, including oncolytic viruses. However, owing to the previously reported tumorigenic potential of NSC cell line after intranasal administration (INA), here we identified the human hepatic stellate cell line (LX-2) as a cell type capable of longer resistance to replication of oncolytic aden...

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Literature Corpus work: f250c97b-c2b1-5c2a-8e9f-1580237c6b8b
DOI: 10.1101/2023.08.16.553513

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