Article

Two miRNAs Efficiently Reprogram Human Fibroblasts into SST Interneurons

2022-03-22

Abstract excerpt

Many neurological disorders stem from defects in or the loss of specific neurons. Dysfunction of γ-aminobutyric acid (GABA)ergic interneurons may cause a variety of neurological and psychiatric disorders such as epilepsy, autism, Alzheimer's disease and depression. Unlike other types of neurons, which can be generated relative easily by direct reprogramming, it is difficult to generate GABAergic neurons by traditi...

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Literature Corpus work: 8211556d-12ea-5149-a6e1-2f4126a83f9b
DOI: 10.21203/rs.3.rs-1463792/v1

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