Back to search

Article

Targeting matrix metalloproteinase-14 disrupts DNA repair and reduces viability in adrenocortical carcinoma

2026-01-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine cancer with limited treatment options and poor prognosis. Identifying novel therapeutic targets requires understanding the molecular drivers of ACC progression and establishing translational models for preclinical validation. <h4>Results</h4> Matrix metalloproteinase-14 (MMP-14) is the most highly expressed M...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f24e1078-ab2d-5e1f-8bc0-18eb6c10a1fe
DOI
10.64898/2026.01.06.697992
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Targeting matrix metalloproteinase-14 disrupts DNA repair and reduces viability in adrenocortical carcinomaDOI 10.64898/2026.01.06.697992
EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressivenessSemantic proximity
A 3D adrenocortical carcinoma tumor platform for preclinical modeling of drug response and matrix metalloproteinase activitySemantic proximity
EZH2 is overexpressed in adrenocortical carcinoma and is associated with disease progression.Semantic proximity
Single Nuclei Sequencing Reveals Intratumoral Cellular Heterogeneity and Replication Stress in Adrenocortical CarcinomaSemantic proximity
H2AFX modulates lung adenocarcinoma cell progression through the PPM1G-MAPK signaling axisSemantic proximity
Integrative multi-omics reveals PARP14 as a key IFNγ-regulated mediator of metastatic progression in Ewing sarcomaSemantic proximity
Epigenetic silencing of RASSF1A deregulates cytoskeleton and promotes malignant behavior of adrenocortical carcinoma.Semantic proximity
Integrated genome-wide analysis of genomic changes and gene regulation in human adrenocortical tissue samplesSemantic proximity
Establishment of a patient-derived adrenocortical carcinoma 3D tumor construct platform for evaluation of therapeutic strategiesSemantic proximity
Elucidating the Role of the Maternal Embryonic Leucine Zipper Kinase in Adrenocortical CarcinomaSemantic proximity
MMP1-induced NF-κB activation promotes epithelial–mesenchymal transition and sacituzumab govitecan resistance in hormone receptor-positive breast cancerSemantic proximity
What is the role of CHCHD2 in adrenal tumourigenesis?Semantic proximity
Select a neighboring publication to make it the new centre.