Article

A 3D adrenocortical carcinoma tumor platform for preclinical modeling of drug response and matrix metalloproteinase activity

2023-01-25

Abstract excerpt

Adrenocortical carcinoma (ACC) has a poor prognosis, and no new drugs have been identified in decades. The absence of drug development can partly be attributed to a lack of preclinical models. Both animal models and 2D cell cultures of ACC fail to accurately mimic the disease, as animal physiology is inherently different than humans, and 2D cultures fail to represent the crucial 3D architecture. Organoids and othe...

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Literature Corpus work: 6a05a08b-006f-545d-8f8e-3716463ea8c8
DOI: 10.1101/2023.01.24.525287

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