Back to search

Article

Intestinal cDC1s provide IL-12 dependent and independent functions required for CD4 <sup>+</sup> T cell-mediated resistance to <i>Cryptosporidium</i>

2023-11-13

Abstract excerpt

Cryptosporidium is an enteric pathogen that is a prominent cause of diarrheal disease. Control of this infection requires CD4 + T cells, though the processes that lead to T cell-mediated resistance have been difficult to assess. Here, Cryptosporidium parasites that express MHCII-restricted model antigens were generated to dissect the early events that influence CD4 + T cell priming and effector function. These...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c5134806-68dd-51f8-8b6a-cbae6447fa96
DOI
10.1101/2023.11.11.566669
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Intestinal cDC1s provide IL-12 dependent and independent functions required for CD4 <sup>+</sup> T cell-mediated resistance to <i>Cryptosporidium</i>DOI 10.1101/2023.11.11.566669
Dendritic cell-mediated responses to secreted <i>Cryptosporidium</i> effectors are required for parasite-specific CD8 <sup>+</sup> T cell responsesSemantic proximity
Immunity to Cryptosporidium: insights into principles of enteric responses to infectionSemantic proximity
ILCs—Crucial Players in Enteric Infectious DiseasesSemantic proximity
Type 1 and type 2 dendritic cell subsets cooperate to maintain intestinal immune tolerance via integrin αvβ8-mediated TGF-β activationSemantic proximity
Transcriptome profiling of pathogen-specific CD4 T cells identifies T-cell-intrinsic caspase-1 as an important regulator of Th17 differentiationSemantic proximity
Intestinal CD4-CD8αβ-TCRαβ+ T cells function as tolerogenic antigen presenting cellsSemantic proximity
The Regulation of CD4+ T Cell Responses during Protozoan InfectionsSemantic proximity
Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective responseSemantic proximity
Dendritic cell-mediated responses to secreted Cryptosporidium effectors promote parasite-specific CD8+ T cell responsesSemantic proximity
Non-coding RNAs in epithelial immunity to<i>Cryptosporidium</i>infectionSemantic proximity
Using two phases of the CD4 T cell response to blood-stage murine malaria to understand regulation of systemic immunity and placental pathology in Plasmodium falciparum infection.Semantic proximity
Targeting type I regulatory T cells to enhance anti-parasitic T helper 1 and T follicular helper cell responses in human malariaSemantic proximity
Select a neighboring publication to make it the new centre.