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Mathematical modeling explains differential SARS CoV-2 kinetics in lung and nasal passages in remdesivir treated rhesus macaques

2020-06-22

Abstract excerpt

Remdesivir was recently demonstrated to decrease recovery time in hospitalized patients with SARS-CoV-2 infection. In rhesus macaques, early initiation of remdesivir therapy prevented pneumonia and lowered viral loads in the lung, but viral loads increased in the nasal passages five days after therapy. We developed mathematical models to explain these results. We identified that 1) drug potency is slightly higher...

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Literature Corpus work
f2485c5a-ac61-5e46-826e-2eea45794ce0
DOI
10.1101/2020.06.21.163550
Open publication

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Mathematical modeling explains differential SARS CoV-2 kinetics in lung and nasal passages in remdesivir treated rhesus macaquesDOI 10.1101/2020.06.21.163550
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