Article
Genetic barrier to resistance: a critical parameter for efficacy of neutralizing monoclonal antibodies against SARS-CoV-2 in a nonhuman primate model.
Journal of virology - 23 Jul 2024
Stahl-Hennig Christiane, Peter Antonia Sophia, Cordsmeier Arne, Stolte-Leeb Nicole, Vestweber Ramona, Socher Eileen, Merida Samuel Alberto, Sauermann Ulrike, Bleyer Martina, Fraedrich Kirsten, Grunwald Thomas, Winkler Thomas H, Ensser Armin, Jäck Hans-Martin, Überla Klaus
Abstract excerpt
The potency of antibody neutralization in cell culture has been used as the key criterion for selection of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for clinical development. As other aspects may also influence the degree of protection in vivo, we compared the efficacy of two neutralizing monoclonal antibodies (TRES6 and 4C12) targeting different epitopes of the receptor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.