Article

Multicellular Spatial Model of RNA Virus Replication and Interferon Responses Reveals Factors Controlling Plaque Growth Dynamics

2021-03-16

Abstract excerpt

Respiratory viruses present major health challenges, as evidenced by the 2009 influenza pandemic and the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Severe RNA virus respiratory infections often correlate with high viral load and excessive inflammation. Understanding the dynamics of the innate immune response and its manifestation at the cell and tissue levels are vital to unders...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 225ec0cb-40c7-573a-bf28-6e36332444b5
DOI: 10.1101/2021.03.16.435618

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multicellular Spatial Model of RNA Virus Replication and Interferon Responses Reveals Factors Controlling Plaque Growth DynamicsDOI 10.1101/2021.03.16.435618Read

A Multiscale Multicellular Spatiotemporal Model of Local Influenza Infection and Immune ResponseSemantic proximity Read

Dynamics of interactions between three major respiratory pathogens in reconstituted human epitheliumSemantic proximity Read

Enhanced viral infectivity and reduced interferon production are associated with high pathogenicity for influenza virusesSemantic proximity Read

Dynamic Culture Improves the Predictive Power of Bronchial and Alveolar Airway Models of SARS-CoV-2 InfectionSemantic proximity Read

A precision-cut lung slice platform for evaluating respiratory virus replication dynamicsSemantic proximity Read

Mathematical Modeling Identifies the Role of Adaptive Immunity as a Key Controller of Respiratory Syncytial Virus (RSV) Titer in Cotton RatsSemantic proximity Read

In Silico Modeling of Virus Particle Propagation and Infectivity along the Respiratory Tract: A Case Study for SARS-COV-2Semantic proximity Read

A Simulation of Semi-Infectious Particles and Genome Complementation Reproduces Interferon Response by Respiratory Epithelial Cells <i>in vitro</i> during Influenza A Virus InfectionSemantic proximity Read

An Ultrasensitive Mechanism Regulates Influenza Virus-Induced InflammationSemantic proximity Read

Mathematical modeling of ventilator-induced lung inflammationSemantic proximity Read

Quantitative modeling of SARS-CoV-2 replication reveals phase-specific bottlenecks and antiviral targetsSemantic proximity Read