Article
Choosing Subsamples for Sequencing Studies by Minimizing the Average Distance to the Closest Leaf.
Genetics - 1 Oct 2015
Kang Jonathan T L, Zhang Peng, Zöllner Sebastian, Rosenberg Noah A
Abstract excerpt
Imputation of genotypes in a study sample can make use of sequenced or densely genotyped external reference panels consisting of individuals that are not from the study sample. It also can employ internal reference panels, incorporating a subset of individuals from the study sample itself. Internal panels offer an advantage over external panels because they can reduce imputation errors arising from genetic...
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