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Article

In situ validation of an intestinal stem cell signature in colorectal cancer.

Gut - 1 Jul 2013

Ziskin Jennifer L, Dunlap Debra, Yaylaoglu Murat, Fodor Imola K, Forrest William F, Patel Rajesh, Ge Nianfeng, Hutchins Gordon G, Pine James K, Quirke Philip, Koeppen Hartmut, Jubb Adrian M

Abstract excerpt

OBJECTIVE: Wnt/Tcf, Lgr5, Ascl2 and/or Bmi1 signalling is believed to define the mouse intestinal stem cell niche(s) from which adenomas arise. The aim of this study was to determine the relevance of these putative intestinal stem cell markers to human colorectal cancer. DESIGN: 19 putative intestinal stem cell markers, including Ascl2 and Lgr5, were identified from published data and an evaluation of a human...

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Share to Adenocarcinoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Neoplasm

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Identifiers

PMID: 22637696
DOI: 10.1136/gutjnl-2011-301195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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