Article

Optimisation of Xenium automated in situ sequencing for PAXgene-fixed tissue samples

2025-02-12

Abstract excerpt

Spatial transcriptomics has transformed the study of gene expression in tissue samples, yet its application to non- standard sample preservation formats beyond fresh frozen and FFPE remains underexplored. PAXgene fixation offers advantages for genomic studies by preserving DNA and RNA without crosslinking but poses challenges for high-quality spatial transcriptomics. Here, we present an optimised workflow for appl...

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Literature Corpus work: f1d0c7c5-e12e-56d4-ab35-1805dfc72e98
DOI: 10.1101/2025.02.11.637091

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