Back to search

Article

Human BMP4 mRNA Encapsulated in Lipid Nanoparticle Delayed Cartilage Degeneration but Has a Limited Enhancement Effect on Bone Healing in Aged Mice

2026-04-10

Abstract excerpt

Segmental bone defects and age-related osteoarthritis (OA) are clinically challenging in terms of treatment. Although preclinical studies have demonstrated efficacy for bone defect healing and OA using ex vivo gene therapy or biomaterial sustain-release delivery, few have translated into clinical therapies due to safety concerns. Bone morphogenetic proteins belong to the TGFβ superfamily and are effective in bone...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f1cfdcf5-5616-50cc-a579-8b76e8d595d9
DOI
10.20944/preprints202604.0770.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Human BMP4 mRNA Encapsulated in Lipid Nanoparticle Delayed Cartilage Degeneration but Has a Limited Enhancement Effect on Bone Healing in Aged MiceDOI 10.20944/preprints202604.0770.v1
Biomaterial Strategies in Osteoarthritis: New Insights Bridging Aging Phenotypes and Hypoxic Microenvironment Pathology.Semantic proximity
Viral and non-viral vectors for gene therapy in the treatment of bone-related disorders: molecular insights and clinical perspectivesSemantic proximity
Bone Morphogenetic ProteinsSemantic proximity
Age-associated spontaneous activation of BMP signaling inhibits the canonical Wnt pathway through ICAT to promote osteoarthritisSemantic proximity
Evaluating the Therapeutic Efficacy of Iopanoic Acid in a DMM-Induced Osteoarthritis Mouse Model and Osteochondral Lesioned Human ExplantsSemantic proximity
Bone defects and future regenerative nanomedicine approach using stem cells in the mutant Tabby mouse model.Semantic proximity
Age-related Impairment of Implant Osseointegration is Associated with Immune Activation and Suppression of Angiogenic, Notch, and Wnt PathwaysSemantic proximity
A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery systemSemantic proximity
Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatmentSemantic proximity
Encapsulation of Rat Bone Marrow Derived Mesenchymal Stem Cells (rBMMSCs) in Collagen Type I Containing Platelet-Rich Plasma for Osteoarthritis Treatment in Rat ModelSemantic proximity
3D-bioprinting a genetically inspired cartilage scaffold with GDF5-conjugated BMSC-laden hydrogel and polymer for cartilage repairSemantic proximity
The recombinant BMP-2 loaded silk fibroin microspheres improved the bone phenotype of mild osteogenesis imperfecta mice.Semantic proximity
Select a neighboring publication to make it the new centre.