Article
The recombinant BMP-2 loaded silk fibroin microspheres improved the bone phenotype of mild osteogenesis imperfecta mice.
PeerJ - 1 Jan 2023
Fu Ting, Liu Yi, Wang Zihan, Jing Yaqing, Zhao Yuxia, Shao Chenyi, Lv Zhe, Li Guang
Abstract excerpt
Osteogenesis imperfecta (OI) is an inherited congenital disorder, characterized primarily by decreased bone mass and increased bone fragility. Bone morphogenetic protein-2 (BMP-2) is a potent cytokine capable of stimulating bone formation, however, its rapid degradation and unanticipated in vivo effects restrict its application. The sustained release characteristic of silk fibroin (SF) microspheres may...
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