Article

Poor control of viral replication in the lung as major driver of early respiratory failure in ventilated patients with COVID-19

2025-08-18

Abstract excerpt

The contribution of active SARS-CoV-2 viral replication to respiratory failure in severe COVID-19 remains unclear. We prospectively analysed bronchoalveolar lavage (BAL) samples from 159 critically ill COVID-19 patients requiring invasive mechanical ventilation (IMV) for SARS-CoV-2 RNA load, replication-competent virus and host immune gene expression. Viral RNA was detected in 84.3% of patients and 60% were positi...

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Literature Corpus work: f1c5675d-c9d5-5241-bf23-59ead961a6f5
DOI: 10.22541/au.175549877.77565027/v1

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