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Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

14 Jul 2021

Abstract excerpt

Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 (COVID-19) and poor outcomes. Here, we analyze the transcriptomes of 611,398 single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in patients with chronic lung diseases. We observe a similar cellular distribution and relative...

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PMID: 34262047
DOI: 10.1038/s41467-021-24467-0

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