Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia

Abstract excerpt

Secondary bacterial pneumonia (2°BP) is associated with significant morbidity following respiratory viral infection, yet remains incompletely understood. In a prospective cohort of 112 critically ill adults intubated for COVID-19, we comparatively assess longitudinal airway microbiome dynamics and the pulmonary transcriptome of patients who developed 2°BP versus controls who did not. We find that 2°BP is...

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• Gut microbiota and health
• Pneumonia and Respiratory Infections
• Respiratory viral infections research