Article

A genome-wide <i>in vivo</i> screen reveals fitness pathways required for streptococcal infective endocarditis

2026-04-10

Abstract excerpt

Infective endocarditis (IE) is a life-threatening disease most often caused by blood-borne bacteria that infect previously damaged cardiac tissue. Despite the importance of this disease, the genetic basis for IE virulence remains poorly defined. Here, we present the first genome-wide in vivo analysis of bacterial fitness in a vertebrate model of IE. We identified 146 genes in Streptococcus sanguinis required for...

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Literature Corpus work: f1bbc758-9a3e-5485-953f-05250b049c4a
DOI: 10.64898/2026.04.07.717129

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