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Article

Genome-wide identification of Streptococcus sanguinis fitness genes in human serum and discovery of potential selective drug targets.

Molecular microbiology - 1 Apr 2021

Zhu Bin, Green Shannon P, Ge Xiuchun, Puccio Tanya, Nadhem Haider, Ge Henry, Bao Liang, Kitten Todd, Xu Ping

Abstract excerpt

Streptococcus sanguinis is a primary colonizer of teeth and is associated with oral health. When it enters the bloodstream, however, this bacterium may cause the serious illness infective endocarditis. The genes required for survival and proliferation in blood have not been identified. The products of these genes could provide a rich source of targets for endocarditis-specific antibiotics possessing greater...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33084151
DOI: 10.1111/mmi.14629
PMCID: PMC8055731

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