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Identification of Virulence Determinants for Endocarditis in Streptococcus sanguinis by Signature-Tagged Mutagenesis

19 Aug 2005

Abstract excerpt

Streptococcus sanguinis is a gram-positive, facultative anaerobe and a normal inhabitant of the human oral cavity. It is also one of the most common agents of infective endocarditis, a serious endovascular infection. To identify virulence factors for infective endocarditis, signature-tagged mutagenesis (STM) was applied to the SK36 strain of S. sanguinis, whose genome is being sequenced. STM allows the...

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Share to Antimicrobial Resistance in Staphylococcus
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PMID: 16113327
DOI: 10.1128/iai.73.9.6064-6074.2005

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