Article

Structural Modelling of the Lumenal Domain of Human GPAA1, the Metallo-Peptide Synthetase Subunit of the Transamidase Complex, Reveals Zinc-Binding Mode and Two Flaps Surrounding the Active Site

2020-06-04

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> The transamidase complex is a molecular machine in the endoplasmic reticulum of eukaryotes that attaches a glycosylphosphatidylinositol (GPI) lipid anchor to substrate proteins after cleaving a C-terminal propeptide with a defined sequence signal. Its five subunits are very hydrophobic; thus, solubility, heterologous expression and complex reconstruction are diff...

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Literature Corpus work: f1bae1b0-3788-52d5-b80d-96dc5d0ac261
DOI: 10.21203/rs.3.rs-32847/v1

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Structural Modelling of the Lumenal Domain of Human GPAA1, the Metallo-Peptide Synthetase Subunit of the Transamidase Complex, Reveals Zinc-Binding Mode and Two Flaps Surrounding the Active SiteDOI 10.21203/rs.3.rs-32847/v1Read

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