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Article

Molecular models of the interface between anterior pharynx-defective protein 1 (APH-1) and presenilin involving GxxxG motifs.

ChemMedChem - 1 Apr 2008

Jozwiak Krzysztof, Krzysko Krystiana A, Bojarski Lukasz, Gacia Magdalena, Filipek Slawomir

Abstract excerpt

Gamma-secretase is an integral membrane protease, which is a complex of four membrane proteins. Improper functioning of gamma-secretase was found to be critical in the pathogenesis of Alzheimer's disease. Despite numerous efforts, the structure of the protease as well as its proteolytic mechanism remains poorly understood. In this work we constructed a model of interactions between two proteins forming...

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Identifiers

PMID: 18061918
DOI: 10.1002/cmdc.200700189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular models of the interface between anterior pharynx-defective protein 1 (APH-1) and presenilin involving GxxxG motifs.PMID 18061918Read ↗

Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.Semantic proximity Read ↗

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.Semantic proximity Read ↗

Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif.Semantic proximity Read ↗

Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization.Semantic proximity Read ↗

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.Semantic proximity Read ↗

Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.Semantic proximity Read ↗

Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage.Semantic proximity Read ↗

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.Semantic proximity Read ↗

Structure of γ-secretase (PSEN1/APH-1B) in complex with Aβ46 provides insights into amyloid-β processing and modulation by the APH-1B isoformSemantic proximity Read ↗

Intramembrane proteolysis by presenilin and presenilin-like proteases.Semantic proximity Read ↗

An atomic structure of human γ-secretase.Semantic proximity Read ↗

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production.Semantic proximity Read ↗

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