Article

Computational Structural Analysis of POLG Variants R627Q and W748S with Model-Variability Controls

2026-08-27

Abstract excerpt

<h4>Background</h4> Comparisons between independently predicted wild-type and missense-variant protein structures can generate mechanistic hypotheses, but small apparent differences may reflect model-selection variability rather than mutation-specific effects. <h4>Methods</h4> Human mitochondrial DNA polymerase gamma (POLG; UniProt P54098) variants p.Arg627Gln (R627Q) and p.Trp748Ser (W748S) were evaluated using...

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Literature Corpus work: f1501e12-fac4-5b82-9dd2-edafb7c8aaf4
DOI: 10.64898/2026.08.25.747108

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