Article

Targeting the N-myc oncoprotein using nanobody technology

2018-01-01

Abstract excerpt

The myc family of oncogenic transcription factors, which includes c-myc, N-myc and L-myc, control major cellular processes such as proliferation and differentiation by integrating upstream signals and orchestrating global gene transcription. They do this largely through dimerising with Max, which together bind to enhancer (E)-box elements in DNA. Myc proteins function similarly but differ in potency and tissue dis...

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Literature Corpus work: f142196a-d643-5ae4-8fe0-695f7db5da22
DOI: 10.17863/cam.25345

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