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Alternative approaches to target Myc for cancer treatment

10 Mar 2021

Abstract excerpt

The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL, which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc, respectively. Myc protein orchestrates diverse physiological processes, including cell proliferation, differentiation, survival, and apoptosis. Myc modulates about 15% of the global transcriptome, and its deregulation rewires the cellular signaling modules...

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PMID: 33692331
DOI: 10.1038/s41392-021-00500-y

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