Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner

22 Mar 2022

Abstract excerpt

Deregulated expression of MYC family oncogenes occurs frequently in human cancer and is often associated with aggressive disease and poor prognosis. While MYC is a highly warranted target, it has been considered “undruggable,” and no specific anti-MYC drugs are available in the clinic. We recently identified molecules named MYCMIs that inhibit the interaction between MYC and its essential partner MAX. Here we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Multiple Myeloma Research and Treatments
Share to Protein Degradation and Inhibitors
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36874405
DOI: 10.1158/2767-9764.crc-21-0019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent MannerPMID 36874405Read ↗

A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferationSemantic proximity Read ↗

A novel inhibitor L755507 efficiently blocks c-Myc–MAX heterodimerization and induces apoptosis in cancer cellsSemantic proximity Read ↗

Turning Up the Heat on MYC: Progress in Small-Molecule InhibitorsSemantic proximity Read ↗

Targeting of the MYCN Protein with Small Molecule c-MYC InhibitorsSemantic proximity Read ↗

Taking on challenging targets: making MYC druggable.Semantic proximity Read ↗

Identification and Pharmacological Inactivation of the MYCN Gene Network as a Therapeutic Strategy for Neuroblastic Tumor CellsSemantic proximity Read ↗

Functional genomics identifies therapeutic targets for MYC-driven cancerSemantic proximity Read ↗

Small-molecule inhibitors of c-Myc transcriptional factor suppress proliferation and induce apoptosis of promyelocytic leukemia cell via cell cycle arrestSemantic proximity Read ↗

Alternative approaches to target Myc for cancer treatmentSemantic proximity Read ↗

Cell-based methods for the identification of MYC-inhibitory small molecules.Semantic proximity Read ↗

MYC as a Target for Cancer Treatment: from Undruggable to Druggable?Semantic proximity Read ↗

Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-MycSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.