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Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/ NLRP3 signaling in rat

2020-05-15

Abstract excerpt

<h4>Background: </h4> Recently, depression has been identified as prevalent and severe mental disorder. However, the mechanisms underlying the depression risk remain elusive. The neuroinflammation and NLRP3 inflammasome activation are known to be involved in the pathology of depression. Dihydrolipoic acid (DHLA) has been reported as a strong antioxidant and exhibits anti-inflammatory properties in various diseases...

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Literature Corpus work
f13dc1e0-4fd3-5b6c-8662-141aeea00611
DOI
10.21203/rs.2.21123/v3
Open publication

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Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/ NLRP3 signaling in ratDOI 10.21203/rs.2.21123/v3
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