Article

The endogenous metabolite hypochlorite activates indoleamine 2,3-dioxygenase-1 for catalysis: Functional and mechanistic implications

2026-04-23

Abstract excerpt

Indolamine 2,3-dioxygenase (IDO1) is a hemoprotein that catalyzes the oxidative cleavage of L-tryptophan (L-Trp) to N’ -formyl-L-kynurenine (L-NFK) along the kynurenine pathway. Its activity depletes L-Trp while initiating a signaling cascade culminating in an immunosuppressive outcome of clinical significance. The generally used in vitro activity assay for IDO1 relies on ascorbic acid and synthetic methylene blu...

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Literature Corpus work: f12aeee9-38cd-5958-baed-b95622409f07
DOI: 10.64898/2026.04.21.719948

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