Article

Vitamin D3 Deficiency Exacerbates Abdominal Aortic Aneurysm Progression Via Complement C3a Activation

2026-06-09

Abstract excerpt

<h4>ABSTRACT</h4> Abdominal aortic aneurysm (AAA) is a chronic inflammatory vascular disease characterized by progressive extracellular matrix degradation, vascular smooth muscle cell (VSMC) loss, and immune cell infiltration, ultimately leading to aortic dilation and rupture. Although vitamin 25(OH)D 3 deficiency has been associated with cardiovascular inflammation, it’s mechanistic role in AAA pathogenesis rem...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1030124-c76d-5aa8-9aac-d0bbc9f32999
DOI: 10.64898/2026.06.05.730431

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vitamin D3 Deficiency Exacerbates Abdominal Aortic Aneurysm Progression Via Complement C3a ActivationDOI 10.64898/2026.06.05.730431Read

Vitamin D Receptor Activation Reduces Angiotensin-II-Induced Dissecting Abdominal Aortic Aneurysm in Apolipoprotein E-Knockout Mice.Semantic proximity Read

Understanding the pathogenesis of abdominal aortic aneurysmsSemantic proximity Read

Identification of Serum Biomarkers and Therapeutic Targets for Aortic Diseases in Obesity through Multi-Omics AnalysisSemantic proximity Read

Proteomic analysis of intraluminal thrombus highlights complement activation in human abdominal aortic aneurysms.Semantic proximity Read

Multi-omics in thoracic aortic aneurysm: the complex road to the simplificationSemantic proximity Read

Role of Complement Cascade in Abdominal Aortic AneurysmsSemantic proximity Read

Protectin D1/GPR37 signaling enhances macrophage-dependent efferocytosis to attenuate experimental abdominal aortic aneurysm formationSemantic proximity Read

Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic targetSemantic proximity Read

Cellular, Molecular and Clinical Aspects of Aortic Aneurysm-Vascular Physiology and Pathophysiology.Semantic proximity Read

Multiomics coupled with vibrational spectroscopy identify early mechanisms of experimental aortic valve stenosisSemantic proximity Read

Integrated Multi-Omics Profiling Reveals Neutrophil Extracellular Traps Promote Aortic DissectionSemantic proximity Read

Crosstalk of platelets with macrophages and fibroblasts aggravates inflammation, aortic wall stiffening and osteopontin release in abdominal aortic aneurysmSemantic proximity Read