Article
Proteomic analysis of intraluminal thrombus highlights complement activation in human abdominal aortic aneurysms.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2013
Martinez-Pinna Roxana, Madrigal-Matute Julio, Tarin Carlos, Burillo Elena, Esteban-Salan Margarita, Pastor-Vargas Carlos, Lindholt Jes S, Lopez Juan A, Calvo Enrique, de Ceniga Melina Vega, Meilhac Olivier, Egido Jesus, Blanco-Colio Luis M, Michel Jean-Baptiste, Martin-Ventura Jose L
Abstract excerpt
OBJECTIVE: To identify proteins related to intraluminal thrombus biological activities that could help to find novel pathological mechanisms and therapeutic targets for human abdominal aortic aneurysm (AAA). APPROACH AND RESULTS: Tissue-conditioned media from patients with AAA were analyzed by a mass spectrometry-based strategy using liquid chromatography coupled to tandem mass spectrometry. Global pathway...
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