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Comparative single-cell lineage tracing identifies distinct adipocyte precursor dynamics in skin and inguinal fat

30 Jul 2025

Abstract excerpt

White adipose tissue supports essential physiological functions through adipocyte precursor cells (APCs), comprising progenitors and preadipocytes, which generate mature adipocytes during depot expansion. Using single-cell RNA sequencing-based lineage tracing, we characterize APCs in skin adipose tissue-a depot uniquely capable of rapid adipogenesis compared with other sites, such as inguinal adipose. We identify...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 40744015
DOI: 10.1016/j.stem.2025.07.004

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