Article

HLA-G gene editing: a novel therapeutic alternative in cancer immunotherapy

2021-01-22

Abstract excerpt

Cancer immunotherapies based mainly on the blockade of immune-checkpoint (IC) molecules by anti-IC antibodies offer new alternatives for treatment in oncological diseases. However, a considerable proportion of patients remain unresponsive to them. Hence, the development of novel clinical immunotherapeutic approaches and/or targets are crucial. In this context, targeting the immune-checkpoint HLA-G/ILT2/ILT4 has ca...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0e76efc-98aa-5991-a8d0-e0275aed7c02
DOI: 10.1101/2021.01.21.427294

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HLA-G gene editing: a novel therapeutic alternative in cancer immunotherapyDOI 10.1101/2021.01.21.427294Read

HLA-G gene editing in tumor cell lines as a novel alternative in cancer immunotherapySemantic proximity Read

HLA-G neo-expression modifies genetic programs governing tumor cell linesSemantic proximity Read

First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G.Semantic proximity Read

The Molecular and Functional Characteristics of HLA-G and the Interaction with Its Receptors: Where to Intervene for Cancer Immunotherapy?Semantic proximity Read

HLA-G engineering reprograms CAR-T cells with an immune privilegeSemantic proximity Read

HLA-G: A New Immune Checkpoint in Cancer?Semantic proximity Read

The Role of HLA-G in Tumor Escape: Manipulating the Phenotype and Function of Immune CellsSemantic proximity Read

Application of Genome Editing Techniques in ImmunologySemantic proximity Read

HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune DiseaseSemantic proximity Read

HLA-G in cancer: a way to turn off the immune systemSemantic proximity Read

HLA-G gene activation in tumor cells involvescis-acting epigenetic changesSemantic proximity Read

Virus-free CRISPR knock-in of a chimeric antigen receptor into <i>KLRC1</i> generates potent GD2-specific natural killer cellsSemantic proximity Read