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The Role of HLA-G in Tumor Escape: Manipulating the Phenotype and Function of Immune Cells

23 Dec 2020

Abstract excerpt

Human leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex class I (MHC I) molecule, and under physiological conditions, its expression is strictly restricted to the maternal-fetal interface and immune-privileged organs where HLA-G is expected to contribute to establishment and maintenance of immune tolerance. However, the expression of HLA-G has been found in various types of tumors,...

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PMID: 33425752
DOI: 10.3389/fonc.2020.597468

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