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HLA-G gene editing in tumor cell lines as a novel alternative in cancer immunotherapy

12 Nov 2021

Abstract excerpt

Cancer immunotherapies based mainly on the blockade of immune-checkpoint (IC) molecules by anti-IC antibodies offer new alternatives for treatment in oncological diseases. However, a considerable proportion of patients remain unresponsive to them. Hence, the development of novel clinical immunotherapeutic approaches and/or targets are crucial.W In this context, targeting the immune-checkpoint HLA-G/ILT2/ILT4 has...

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PMID: 34773056
DOI: 10.1038/s41598-021-01572-0

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